factor v and viii inhibitor in patients with combined factor v and viii deficiency

patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhibitors and two patients had none. because factor v and factor viii share approximately 40% amino acid sequence homology in their a and c domains, it remains to be elucidated if it is one molecule that recognizes both factor v and viii or whether there are two inhibitor molecules against common sites.